In September 2021 YouThinkGreen (YTG) and ISC3 were offering a masterclass in sustainable chemistry for Egyptian start-ups who are driving the change in energy, waste management and circular economy towards a sustainable future. Within the three hours interactive masterclass six start-ups were introduced to the basic concepts of sustainable chemistry and importance for start-ups. Existing and upcoming business opportunities were presented and discussed in the light of chemistry regulation and the EU-Taxonomy. Based on this the start-ups were using a provided sustainability checklist to explain and illustrate business opportunities of their start-ups when the underlying sustainability criteria are addressed. Thereby, each start-up was individually exploring which sustainability criteria could be prioritized and addressed by their technology and business model.